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Animal Models in Cardiovascular Research by David R. Gross D.V.M., Ph.D. (auth.)

By David R. Gross D.V.M., Ph.D. (auth.)

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75mg/ kg IV (Apomorphine OC Recarrnended analgesic and sedative dose 20 mg/kg ? subof 25 mg/kg, IP Isolated pulmonary artery strips Response to lethal doses Doxapam Decapitated 30 min. after morphine dose. Aortic strips and portal vein segments measured for isanetric contractile tension, dose response curves to epinephrine, angiotensin II and potassium chloride No injection. Dose-dependent decrease in aortic pressure, at higher doses a marked decrease in heart rate. Effects shown to be central in origin and mainly due to stimulation of a Dopamine receptor, sane peripheral effects also probable Effects within 15 min.

Umbilical vein glucose levels were significantly decreased and fetal glucose uptake was markedly decreased. 2: IV IV IV Large renal vascular dilation characterized by a 22% decrease in resistance and an 18% increase in flow. There was an increase in heart rate, a decrease in mean aortic pressure, an increase in cardiac output initially and then a significant decrease. Systemic resistance decreased. The iliac vasculature showed a 39% decrease in resistance with a 40% increase in flow while the mesenteric vasculature had a 40% decrease in flow and an 89% increase in resistance Decreased cardiac output, decreased mean aortic pressure, mild renal vascular dilation characterized by a 10% decrease in renal vascular resistanced and a 5% increase in renal blood flow.

16 Guinea Pigs Cheek-pouch preparation, anesthesia not described. , sham treated control group ? 15 Hansters injection. e. 17 SWine No change in maternal or fetal aortic blood pressure or acid-base status. No change in maternal central venous pressure, systemic resistance, pulmonary artery pressure, cardiac output or intrauterine pressure. Small but significant decrease in maternal heart rate and uterine blood flow at 120 min post injection No data provided No change in stroke volume, during normoxia no change in myocardial oxygen consumption but during hypoxia myocardial oxygen consumption decreased.

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