By Carolyn A. Staton, Claire Lewis, Roy Bicknell
Chapter 1 Endothelial telephone Biology (pages 1–38): Femke Hillen, Veerle Melotte, Judy R. van Beijnum and Arjan W. Griffioen
Chapter 2 Endothelial telephone Proliferation Assays (pages 39–50): Wen?Sen Lee
Chapter three Endothelial mobilephone Migration Assays (pages 51–64): Christos Polytarchou, Maria Hatziapostolou and Evangelia Papadimitriou
Chapter four Tubule Formation Assays (pages 65–87): Ewen J. Smith and Carolyn A. Staton
Chapter five Modelling the results of the Haemodynamic surroundings on Endothelial cellphone Responses suitable to Angiogenesis (pages 89–103): Gerard B. Nash and Stuart Egginton
Chapter 6 entire or Partial Vessel Outgrowth Assays (pages 105–121): Cindy H. Chau and William D. Figg
Chapter 7 Assaying Endothelial–Mural mobilephone Interactions (pages 123–137): Melissa ok. Nix and Karen ok. Hirschi
Chapter eight Assays for Membrane and Intracellular Signalling occasions (pages 139–166): Vittorio Tomasi, Cristiana Griffoni, Spartaco Santi, Patrizia Lenaz, Rosa Anna Iorio, Antonio Strillacci and Enzo Spisni
Chapter nine Implantation of Sponges and Polymers (pages 167–182): Silvia P. Andrade, Monica A. N. D. Ferreira and Tai?Ping Fan
Chapter 10 Angiogenesis Assays within the Chick (pages 183–201): Andries Zijlstra, David Mikolon and Dwayne G. Stupack
Chapter eleven Corneal Angiogenesis Assay (pages 203–228): Siqing Shan and Mark W. Dewhirst
Chapter 12 Dorsal Air Sac version (pages 229–238): Sei Yonezawa, Tomohiro Asai and Naoto Oku
Chapter thirteen Chamber Assays (pages 239–263): Michael D. Menger, Matthias W. Laschke and Brigitte Vollmar
Chapter 14 Tumour types: research of Angiogenesis in vivo (pages 265–291): Sven A. Lang and Oliver Stoeltzing
Chapter 15 Angiomouse: Imageable versions of Angiogenesis (pages 293–310): Robert M. Hoffman
Chapter sixteen options and Advances in Vascular Imaging in Danio Rerio (pages 311–326): Kenna R. turbines Shaw and Brant. M. Weinstein
Chapter 17 organic and scientific Implications of Recruitment of Stem Cells into Angiogenesis (pages 327–340): Gianluigi Castoldi, Antonio Cuneo and Gian Matteo Rigolin
Chapter 18 tools for tracking of the Anti?Angiogenic job of brokers in sufferers: Novel Trial layout (pages 341–359): Shannon Smiley, Michael ok. ok. Wong and Shaker A. Mousa
Chapter 19 an outline of present Angiogenesis Assays: selection of Assay, Precautions in Interpretation, destiny standards and instructions (pages 361–374): Robert Auerbach
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Additional info for Angiogenesis Assays: A Critical Appraisal of Current Techniques
The main member of the VEGF family of growth factors is VEGF-A. Exon splicing of the human 16 CH1 ENDOTHELIAL CELL BIOLOGY VEGF-A gene results in seven isoforms that have different properties. The three major isoforms, named after their molecular size, are VEGF121, VEGF165 and VEGF189. The VEGF family also includes VEGF-B, VEGF-C, VEGF-D and placental growth factor (PlGF). VEGF-B is an angiogenic protein related to VEGF-A, although it acts on a different set of tyrosine kinase receptors. VEGF-C and VEGFD have been shown to act as lymphangiogenic growth factors.
1999). , 2000; Shubik and Warren, 2000) because evidence that these patterned networks contributed to tumour blood flow appeared to be lacking. Nowadays several research groups are seeking the molecular mechanisms behind vasculogenic mimicry and proof of its contribution to blood flow. Endothelial cells also contribute to the formation of lymph vessels. , 2005; Alitalo and Carmeliet, 2002). It is hypothesized that venous endothelial cells become responsive to lymphatic signals, differentiate and make lymphatic sprouts.
BFGF signalling occurs through four high affinity tyrosine kinase transmembrane receptors (FGFR1-4). It is produced by many cells, including macrophages and tumour cells, and subsequently secreted into the extracellular matrix. At the start of angiogenesis, it can be released from the matrix. bFGF expression can be downregulated by interferon-a and -b. There is an intricate interaction with other growth factors, such as VEGF, that results in a synergistic action in many endothelial cell functions.