Home Medicine • Anaesthesia, Pain, Intensive Care and Emergency A.P.I.C.E.: by K. Hillman (auth.), Antonino Gullo M.D. (eds.)

Anaesthesia, Pain, Intensive Care and Emergency A.P.I.C.E.: by K. Hillman (auth.), Antonino Gullo M.D. (eds.)

By K. Hillman (auth.), Antonino Gullo M.D. (eds.)

Developing sectors within the in depth Care box – and in serious Care medication normally – require particular degrees of competence having a related universal denominator: an in-depth wisdom of human pathophysiology. even if this quantity offers lots of subject matters in consistent evolution, as witnessed through the gathering of chapters compiled by means of numerous researchers, this version contains, specifically, fields within which decision-making on the patient’s bedside prevails over theoretical argumentation. In different phrases, the 1st and greatest message this variation desires to supply is for the reader to concentration his/her awareness on evidence-based medicine.

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Extra resources for Anaesthesia, Pain, Intensive Care and Emergency A.P.I.C.E.: Proceedings of the 21st Postgraduate Course in Critical Care Medicine Venice-Mestre, Italy — November 10–13, 2006

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Cell 64:1057–1068 21. Jenkins RG, Su X, Su G et al (2006) Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. J Clin Invest 116:1606–1614 22. Dhainaut JF, Charpentier J, Chiche JD (2003) Transforming growth factor-beta: a mediator of cell regulation in acute respiratory distress syndrome. Crit Care Med 31:S258–264 23. Kaminski N, Allard JD, Pittet JF et al (2000) Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis.

Koutsoukou, J. Milic-Emili pressure gradient that will permit flow and movement of gas. This can be accomplished by the respiratory muscles or by artificial ventilation during anaesthesia and/or acute respiratory failure. Mechanical ventilation can readily sustain adequate alveolar ventilation, improve arterial blood gases, and unload the patient’s respiratory muscles. However, the mode and settings of a ventilator can significantly influence the course of a disease and the ultimate clinical outcome and may cause severe, life-threatening complications.

These are achieved by the unique design of the lung, which ensures that air and blood are kept in intimate contact—though separate—to allow gas exchange, while maintaining its integrity in the face of the magnitude of insults that inevitably accompany a lifetime of exposure to ambient air and mechanical stress during cyclic breathing. Despite the anatomical complexity of the lung, functionally it can be divided into the bronchial tree and the respiratory zone. The bronchial tree consists of the trachea, which bifurcates into the main bronchi, which in turn branch into lobar, segmental, and subsegmental bronchi and end in bronchioles, which lack cartilage and are about 1 mm in diameter.

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