By Robert A. Goodnow Jr.
This publication comprehensively describes the advance and perform of DNA-encoded library synthesis know-how. jointly, the chapters aspect an method of drug discovery that provides an enticing addition to the portfolio of present hit new release applied sciences comparable to high-throughput screening, structure-based drug discovery and fragment-based screening. The book:
- Provides a worthwhile advisor for figuring out and using DNA-encoded combinatorial chemistry
- Helps chemists generate and monitor novel chemical libraries of huge measurement and caliber
- Bridges interdisciplinary components of DNA-encoded combinatorial chemistry – artificial and analytical chemistry, molecular biology, informatics, and biochemistry
- Shows medicinal and pharmaceutical chemists how you can successfully expand on hand “chemical area” for drug discovery
- Provides professional and up to date precis of said literature for DNA-encoded and DNA-directed chemistry know-how and methods
Read or Download A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery PDF
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Additional resources for A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery
4. Complementary base pairing in DNA. encode. The formation of a double helix is driven by hydrogen bonding between the bases of opposite strands and van der Waals interactions arising from stacking of the bases. Hydrogen bonding between bases occurs in a specific manner. 4). This means that the opposite strands in a DNA helix are complementary; the sequence of one strand can be used to determine the sequence of the other strand. A DNA molecule that has a double-helical structure is often called a DNA duplex.
Template-dependent DNA polymerases can only generate DNA chains by adding complementary nucleotides to the free 3′-hydroxyl end of an annealed complementary strand—the primer. Consequently, a new strand is synthesized in the 5′ to 3′ direction. This poses a problem with replication of a duplex because two unwound template strands from the duplex are running antiparallel to each other but both of them can only be synthesized in the 5′ to 3′ direction. One strand, called a leading strand, can be synthesized continuously because its polarity is consistent with the direction of duplex unwinding and polymerase action.
Such compounds are often recrystallized solids, highly pure, of unquestioned identity, well characterized, and available in multiple milligram quantities. Given the one-at-a-time synthetic approach, synthetic chemists applied much effort to make molecules with diverse substitution patterns for which reagents may not have been readily available and, therefore, required additional synthesis. Such requirements set a high hurdle for the combinatorial chemists hoping to use the power of an organization’s HTS engines to test library designs.